Defective Vav Expression and Impaired F-actin Reorganization in a Subset of Common Variable Immunodeficiency Patients with T- Cell Defects
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چکیده
DEFECTIVE VAV EXPRESSION AND IMPAIRED F-ACTIN REORGANIZATION IN A SUBSET OF COMMON VARIABLE IMMUNODEFICIENCY PATIENTS WITH TCELL DEFECTS Silvia ROSSI PACCANI, Marianna BONCRISTIANO, Laura PATRUSSI, Cristina ULIVIERI, Andreas WACK, Silvia VALENSIN, Tim R. HIRST, Amedeo AMEDEI, Gianfranco DEL PRETE, John L. TELFORD, Mario M. D'ELIOS and Cosima T. BALDARI Department of Evolutionary Biology, University of Siena, Siena, Via Aldo Moro 2, 53100 Siena, Italy; Chiron Research Center, Via Fiorentina 1, 53100 Siena, Italy; School of Molecular & Microbial Biosciences, The University of Sydney, Sydney NSW 2006, Australia; Department of Internal Medicine and Immunoallergology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
منابع مشابه
Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects.
Common variable immunodeficiency (CVID) is a primary immune disorder characterized by impaired antibody production, which is in many instances secondary to defective T-cell function (T-CVID). We have previously identified a subset of patients with T-CVID characterized by defective T-cell receptor (TCR)-dependent protein tyrosine phosphorylation. In these patients, ZAP-70 fails to be recruited t...
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